Peripheral neuropathy is a disorder of the peripheral nervous system, the vehicle that allows communication from the brain and spinal cord to the rest of the body (arms, legs, face). It often causes weakness, numbness, and pain - usually in the hands or feet. Peripheral neuropathy can result from traumatic injuries, infections, metabolic problems, inherited causes, and exposure to toxins (including medications). Common conditions that lead to peripheral neuropathy include diabetes and chemotherapy. Regardless of the cause, poor blood circulation and inflammation are factors in all cases of peripheral neuropathy.